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Key Projects & Woking Groups

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Key Projects & Woking Groups

  • PURSE (Theme I)

    Development of theranostic agents for photodynamic / photothermal treatment of oral/lung cancer and related diseases. 

     
    Project 1 :
    Title : 
    - Design and development of theranostic agents.
    - Synthesis and study of photoogysical aspects of NIR absorbing sensitizers.  
    Principle Investigator of Theme I : Dr. D. Ramaiah, Chair Professor, Department of Chemistry, BITS Pilani, Hyderabad Campus
     
    Project 2 :
    Title : Synthesis and study of photoogysical studies of Theranostic agents.
    Co-Investigator of Theme I : Dr. Manab Chakraborty, Associate Professor, Department of Chemistry, BITS Pilani, Hyderabad Campus
     
    Project 3 :
    Title : Quantification of singlet oxygen produced for suitable photosensitizer molecules and Two-photon excited PDT using confocal imaging.
    Co-Investigator of Theme I : Dr. Amit Nag, Associate Professor, Department of Chemistry, BITS Pilani, Hyderabad Campus 
     
    Project 4 :
    Title : Development of microneedle-based drug delivery device containing photosensitizers and antibodies and its evaluation in in-vitro and in-vivo cancer models.
    Co-Investigator of Theme I : Dr. Venkata Vamsi Krishna Venuganti, Associate Professor, Department of Pharmacy, BITS Pilani, Hyderabad Campus 
     
     
     
     
     Objectives:
     
    • Design of novel BODIPY, aza-BODIPY, porphyrin and chlorin based sensitizers and their nanoparticles (NPs) for imaging and PDT.
    • Effective conjugation of these sensitizers and NPs with folic acid and antibodies for the targeted PDT / PTT.
    • Development of localized delivery approach using microneedles and NPs for the targeted PDT / PTT.
    • Demonstration of combination therapy employing PDT / PTT / Cetuximab and efficacy comparison with the clinically FDA approved photosensitizers, Photofrin@ & Foscan@ 
     
    Deliverables 
     
    • A realistic route to develop effective theranostic agents suitable for both PDT, PPT, and the combined treatment to fight against oral/lung cancer.
    • Introduction and improvement of an efficient strategy to combine imaging and therapy as the best choice.
    • Collaboration with hospitals and pharmaceutical companies, who are engaged in newer technological developments with a target to develop the best possible solutions for oral/lung cancer.
    • IPR protection through patents and publications of results in high-impact journals.
    • Early detection and adequate treatment can be a solution and the proposed theranostic probes are expected to be best suited for such applications. 
     
     
     

  • PURSE (Theme II)

    Development of 2D materials based sensor systems for rapid diagnosis of human diseases through analysis of exhaled breath

     
    Project 1 :
    Title : Design, fabrication, testing and prototyping of breath analyzer sensor system.
    Principle Investigator of Theme II : Dr. Arnab Hazra, Assistant Professor, Department of Electrical & Electronics Engineering, BITS Pilani, Hyderabad Campus
     
    Project 2 :
    Title : Detection and differentiation of different stages of diseases and standardization of the prototype breath analyzer.
    Co-Investigator of Theme II : Dr. Syamantak Mazumdar, Assistant Professor, Department of Biological Sciences, BITS Pilani, Pilani Campus
     
    Project 3 :
    Title : Synthesis and Characterization of nanomaterials for selective chemical sensing.
    Co-Investigator of Theme II : Dr. Subhashis Gangopadhyay, Assistant Professor, Department of Physics, BITS Pilani, Pilani Campus 
     
    Project 4 :
    Title : CVD growth of Emerging 2D materials and its electrical characterization.
    Co-Investigator of Theme II : Dr. Parikshit Sahitya, Assistant Professor, Department of Electrical & Electronics Engineering, BITS Pilani, Hyderabad Campus