Description:
The present invention relates to a device with double-sided herringbone structures for enrichment of CAR-T cells using a continuous-flow microfluidic device.
Key Features & Benefits:
The final design provides a microfluidic device comprising of
• 2 pairs of hexagonal channels connected via 1 inlet and 2 outlets
• The herring-bone structure is being utilized to optimize cell capture and retention within the individual channels.
Benefits include that:
• They require less reagents and samples as input, cutting down a huge cost interms of device maintenance and operations.
• They are easily portable and can be used on-field.
• Easier to handle.
• They are made of polymer, hence function like a throughput device and can also be reused multiple times.
• Being smaller in size, they require less space for storage.
• user friendly.
• Being small in size and made of relatively cheap material, the cost of production of these devices is low.
Innovator(s): Jegatha Nambi Krishnan, Prasanna Gururaj Joshi, Arya Agarwal, Rai Divakar, Hegde Ritvik, Singh Sarthak, Department of Chemical Engineering, Birla Institute of Technology and Science - Pilani, K K Birla Goa Campus
Potential Application& Industries:
The primary application of the invention will be ‘Monitoring the CAR-T cells in a Clinical Setting’. This is a necessary function in order to ensure the viability of the cells before transfusing them into the patient’s body for treatment
Patent Status: Filed in India
Patent#: 202111058598
Is proof-of-concept (PoC) available? Yes
Current TRL Level: 3
Any other /relevant information:
The profiles for pressure, velocity along with the particle trajectory within blood for the device have been obtained using COMSOL Multiphysics.
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