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Patent

 Patents granted

1. Anupama Mittal, Kishan S. Italiya, Samrat Mazumdar, Deepak Chitkara. Surfactant free, self-assembling micelles of fatty acid conjugated to hydrophilic drug and method for preparing the same. Indian Patent # 389948 Grant Dtd: 22/2/22.

2. Anupama Mittal, Kishan S. Italiya, Samrat Mazumdar and Deepak Chitkara. Orally active nanoformulation of Lisofylline and composition thereof. Indian Patent # 395354 Grant Dtd: 25/4/22

3.  Deepak Chitkara, Deepak K. Sahel, Kishan S. Italiya, Saurabh Sharma, Shruti Shah and Anupama Mittal. A Drug Conjugate and method of preparation thereof. Indian Patent # 393113 Grant Dtd: 26/3/22

4. Deepak Chitkara, Sudeep S. Pukale, Arihant K Singh, Anupama Mittal, Saurabh Sharma A lipid-polymer hybrid nanoparticle. A lipid-polymer hybrid nanoparticle. Indian Patent # 393113 Grant Dtd: 26/3/22

 

Patent filed

1.Anupama Mittal, Shubham A Salunkhe, Kiran Bajaj, Deepak Chitkara. Cationic polymer holding therapeutically active ingredient for sustained release and method of preparing the same. Indian patent application #202311043000 filed on Jun 27 2023.
2. Anupama Mittal, Shubham A Salunkhe, Kiran Bajaj, Deepak Chitkara. Polymeric Nano complexes holding therapeutically active ingredient for sustained release and method of preparing the same. Indian patent application #202311043001 filed on Jun 27 2023.
3. Deepak Chitkara, Prabhjeet Singh, Deepak K. Sahel, Reena Jatyan, Anupama Mittal, Arihant K Singh, Shubham A Salunkhe. Polymeric  Nano-Formulation For Delivery Of Temozolomide And Method Of Preparing The Same. Indian patent application #202311047526 filed on July 14 2023.
4. Anupama Mittal, Arihant K Singh, Shubham A Salunkhe, Deepak Chitkara. Formulation of peptide nano-complexes for delivery of peptide and method of preparation. filed on July 14 2023.Indian patent application #202311047523 
5. Deepak Chitkara, Deepak K. Sahel, Kishan S. Italiya, Saurabh Sharma, Shruti Shah, Anupama Mittal, Reena Jatyan. A Self- Assembling Drug Conjugate and method of preparation thereof.  Indian patent application #201911018304 filed on May 06 2020.
6. Applicant- Incisive Element LLC., USA, Inventor: Deepak Chitkara, Sudeep S. Pukale, Arihant K Singh, Anupama Mittal. A lipid-polymer hybrid nanoparticle. Indian patent application #Temp/E-1/4573/2019-Mum filed on February 02, 2019.
7. Deepak Chitkara, Sudeep S. Pukale, Arihant K Singh, Anupama Mittal, Saurabh Sharma A lipid-polymer hybrid nanoparticle. PCT # PCT/IB2020/050819 filed on Feb 03 2020

Publications

Edited Book

Deepak Chitkara, Anupama Mittal, and Ram I. Mahato, "Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology", CRC Press, Taylor Francis, Florida, USA, ISBN: 9781351978378, Release Date: 03/09/2018 
 
 Research/Review articles
  1. Human umbilical cord blood-mesenchymal stem cell derived exosomes as an efficient nanocarrier for Docetaxel and miR-125a: Formulation optimization and anti-metastatic behavior. Moumita Basak, Biswajit Sahoo, Dharmendra Kumar Chaudhary, SaiBhargav Narisepalli, Swasti Tiwari, Deepak Chitkara, Anupama Mittal. Life Sciences 2023, 322, 121621.
  2. Temozolomide-fatty acid conjugates for glioblastoma multiforme: In vitro and in vivo evaluation. Reena Jatyan, Deepak Kumar Sahel, Prabhjeet Singh, Rajeev Sakhuja, Anupama Mittal, Deepak Chitkara. Journal of Controlled Release 2023, 359, 161-174.
  3. Asiaticoside polymeric nanoparticles for effective diabetic wound healing through increased collagen biosynthesis: In-vitro and in-vivo evaluation. Saibhargav Narisepalli, Shubham A. Salunkhe, Deepak Chitkara, Anupama Mittal (International Journal of Pharmaceutics, 631, 122508)
  4. Topical delivery of Anti-VEGF nanomedicines for treating psoriasis. Abhay Tharmatt, Deepak Kumar Sahel, Kaisar Raza, Murali Monohar Pandey, Anupama Mittal, Deepak Chitkara. Journal of Drug Delivery Science and Technology 2023, 83, 104365.
  5. Immunocyte Derived Exosomes: Insight into the Potential Chemo-immunotherapeutic Nanocarrier Targeting the Tumor Microenvironment. Moumita Basak, Dharmendra Kumar Chaudhary, Ryou-u Takahashi, Yuki Yamamoto, Swasti Tiwari, Hidetoshi Tahara, Anupama Mittal. ACS Biomaterials Science & Engineering, 2023, 9, 20-39.
  6. Lipopolymeric nanocarrier enables effective delivery of CRISPR/Cas9 expressing plasmid. Deepak Kumar Sahel, Sangam Giri Goswami, Reena Jatyan, Anupma Kumari, Anupama Mittal, Sivaprakash Ramalingam, Deepak Chitkara. Macromolecular Rapid Communications, 2023, 2300101.
  7. Cationic lipopolymeric nanoplexes containing the CRISPR/Cas9 ribonucleoprotein for genome surgery. Deepak Kumar Sahel, Mohd Salman, Mohd Azhar, Sangam Giri Goswami , Vivek Singh, Manu Dalela, Sujata Mohanty , Anupama Mittal, Sivaprakash Ramalingam, Deepak Chitkara Journal of Material Chemistry B 2022, 10, 7634-7649
  8. Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme.ReenaJatyan,Prabhjeet Singh, Deepak K Sahel, Y G Karthik, Anupama Mittal,Deepak Chitkara. (Journal of Controlled Release, 2022, 350, 494-513)
  9. Exploration of lipid based nano carriers as drug delivery systems in diabetic foot ulcer. Bhaskar Kandregula, Saibhargav N., Deepak Chitkara, Anupama Mittal (Molecular Pharmaceutics,2022, 19, 1977–1998)
  10. Delivery strategies for CRISPR/Cas Genome editing tool for retinal dystrophies: challenges and opportunities. Aayushi Lohia, Deepak Kumar Sahel, Mohammad Salman, Vivek Singh, Indumathi Mariappan, Anupama Mittal, Deepak Chitkara (Asian Journal of Pharmaceutical Sciences, 2022, 17, 153-176)
  11. Role of chain length and degree of unsaturation of fatty acids on physicochemical and pharmacological behaviour of drug-fatty acid conjugates in diabetes. Arihant Kumar Singh, Kishan Italiya, Saibhargav Narisepalli, Deepak Chitkara, Anupama Mittal (Journal of Medicinal Chemistry, 2021, Accepted). 
  12. Lipid based Nanocarriers for effective Drug Delivery and Treatment of Diabetes Associated Liver Fibrosis. Shubham Salunkhe, Deepak Chitkara, Ram I. Mahato, Anupama Mittal (Advanced Drug Delivery Reviews, 2021, 173, 394-415).
  13. Folate Targeted Hybrid Lipo- Polymeric Nanoplexes Containing Docetaxel and miRNA 34a for Breast Cancer Treatment.  Saurabh Sharma, Sudeep Pukale, Deepak Kumar Sahel, Prabhjeet Singh, Anupama Mittal, Deepak Chitkara (Materials Science & Engineering C, 2021, Accepted)
  14. 2,2-Bis(hydroxymethyl) propionic acid based cyclic carbonate monomers and their (co)polymers as advanced materials for biomedical applications. Imran Ansari, Prabhjeet Singh, Anupama Mittal, Ram I Mahato, Deepak Chitkara.(Biomaterials, 2021, 275, 120953).
  15. Nanoparticulate tablet dosage form of lisofylline-linoleic acid conjugate for type 1 diabetes: in situ single-pass intestinal perfusion (SPIP) studies and pharmacokinetics in rat. Italiya, K.S., Singh, A.K., Chitkara, D., Mittal A. (AAPS PharmSci Tech 22, 2021, 114. https://doi.org/10.1208/s12249-021-01980-5).
  16. Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers. Samrat Mazumdar, Deepak Chitkara, Anupama Mittal. (Acta Pharmaceutica Sinica B, 2021, 11, 903-924).
  17. Opportunities and Challenges of Fatty Acid Conjugated Therapeutics. Medha Bhat, Reena Jatyan, Anupama Mittal, Ram I Mahato, Deepak Chitkara. (Chemistry and Physics of Lipids, 2021, 236, 105053).
  18. Nano-enabled topical delivery of anti-psoriatic small molecules, Medha Bhat, Sudeep Pukale, Saurabh Singh, Anupama Mittal, Deepak Chitkara.(Journal of Drug Delivery Science and Technology, 2021, 62, 102328).
  19. Therapeutic agents for targeting desmoplasia: Current status and emerging trends. Tania Nandi, Sai Pradyuth, Arihant Kumar Singh, Deepak Chitkara, Anupama Mittal. (Drug Discovery Today, 2020, S1359-6446, 30365-72).
  20. Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance Shubham Salunkhe, Dheeraj, Moumita Basak, Deepak Chitkara, Anupama Mittal. (Journal of Controlled Release, 2020, 326, 599-614)
  21. RNAi Nanotherapeutics for treatment of Glioblastoma Multiforme. Prabhjeet Singh, Aditi Singh, Shruti Shah, Jalpa Vatalia, Anupama Mittal and Deepak Chitkara. (Molecular Pharmaceutics, 2020, 17, 4040-4066)
  22. Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice. Sudeep Sudesh Pukale, Saurabh Sharma, Manu Dalela, Arihant kumar Singh, Sujata Mohanty, Anupama Mittal, Deepak Chitkara.  (Acta Biomaterialia, 2020, 115,393-409)
  23. Docetaxel and its nanoformulations: how delivery strategies could impact the therapeutic outcome? Saurabh Sharma, Sudeep Sudesh Pukale, Anupama Mittal, Deepak Chitkara. (Therapeutic delivery, 2020, 11, 755-759)
  24. Italiya S, Kishan, Basak Moumita, Mazumdar Samrat, Sahel Deepak, Shrivastava Richa, Chitkara Deepak, Mittal Anupama. A scalable self-assembling micellar system for enhanced oral bioavailability and efficacy of lisofylline for treatment of type-I diabetes (Molecular Pharmaceutics, 2019, 16, 12, 4954–4967)
  25. Harsha P J, Nagarani thotakura, Manish Kumar, Saurabh Sharma, Anupama Mittal, Rajneet Kaur Khurana, Bhupinder Singh, Poonam Negi, Kaisar Raza. A Novel PEGylated Carbon Nanotube Conjugated Mangiferin: An Explorative Nanomedicine for Brain Cancer Cells (Journal of Drug Delivery Science Technology, 2019, 53, 101186)
  26. Deepak K. Sahel, Anupama Mittal, Deepak Chitkara. CRISPR/Cas system for genome editing: progress and prospects as therapeutic a tool (Journal of Pharmacology and Experimental Therapeutics, 2019, 370, 725-735)
  27. Ishit S. Kothari, Samrat Mazumdar, Saurabh Sharma, Kishan S Italiya, Anupama Mittal, Deepak Chitkara. Docetaxel and alpha-lipoic acid co-loaded nanoparticles for cancer therapy (Therapeutic Delivery, 2019, 10, 227-240)
  28. Ishit S. Kothari, Kishan S Italiya, Saurabh Sharma, Anupama Mittal, Deepak Chitkara. A rapid and precise HPLC -UV method for simultaneous determination of alpha-lipoic acid and docetaxel in lipid based nano-formulations (Journal of Chromatographic Sciences, 2019, 56, 888-894)
  29. Kishan S. Italiya, Samrat Mazumdar, Saurabh Sharma,Deepak Chitkara Anupama Mittal. Self assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus (Nanomedicine: Nanotechnology, Biology and Medicine: 2018, 15, 175-187)
  30. Siddharth Uppal, Kishan S. Italiya, Deepak Chitkara Anupama Mittal. Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: an emerging paradigm for effective therapy (Acta Biomater., 2018, 81, 20-42)
  31. Upendra Bulbake, Sonam Jain, Neeraj Kumar, Anupama Mittal. Curcumin loaded biomimetic composite graft for faster regeneration of skin in diabetic wounds. (J. Drug Deliv. Sci. Technol., 47, 12-21)
  32. Ishit S. Kothari, Kishan S Italiya, Saurabh Sharma, Anupama Mittal, Deepak Chitkara. A rapid and precise HPLC -UV method for simultaneous determination of alpha-lipoic acid and docetaxel in lipid based nano-formulations. (J. Chromato. Sci., 56, 888-894)
  33. Saurabh Sharma, Samrat Mazumdar, Kishan S italiya, Tushar Date, Ram I Mahato, Anupama Mittal, Deepak Chitkara. Cholesterol and Morpholne Grafted Cationic Amphiphilic Copolymers for miRNA-34a Delivery (Mol. Pharm. 2018, 15, 2391-2402)
  34. Samrat Mazumdar, Kishan S italiya, Saurabh Sharma, Deepak Chitkara, Anupama Mittal. Effective cellular internalization, cell cycle arrest and improved pharmacokinetics of Tamoxifen by cholesterol based lipopolymeric nanoparticles. (Int. J. Pharm., 2018, 543, 96-106).
  35. Tushar Date, Vaishnavi Nimbalkar, Jyotsna Kamat, Anupama Mittal, Ram I Mahato, Deepak Chitkara. Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics. (J. Control. Release, 2018, 271, 60-73).
  36. Kishan S. Italiya, Saurabh Sharma, Ishit Kothari, Deepak Chitkara, Anupama Mittal*. Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rats. (Journal of Chromatography B, 2017, 1061–1062, 49–56)
  37. Saurabh Sharma, Kishan Italiya, Anupama Mittal, Deepak Chitkara, New strategies for cancer management: How can Temozolomide carrier modifications improve its delivery? (Therapeutic delivery, 2017; 8, 775-477)
  38. Deepak Chitkara, Saurabh Singh, Anupama Mittal, Nano-carrier based co-delivery of small molecules and siRNA/miRNA for treatment of cancer. (Therapeutic delivery, 2016,7, 245-255)
  39. Anupama Mittal and Deepak Chitkara. Structural modifications in polymeric micelles to impart multifunctionality for improved drugdelivery. (Therapeutic delivery, 2016, 7, 73-87)
  40. Anupama Mittal, Deepak Chitkara, Stephan W. Behrman and Ram I. Mahato. Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer. (Biomaterials, 2014, 35, 7077-87).
  41. Anupama Mittal and Neeraj Kumar A new, bioactive, antibacterial-eluting, composite graft for infection-free wound healing. (Wound Repair Regen. 2014, 22, 527-36).
  42. Deepak Chitkara, Anupama Mittal, and Ram I. Mahato. miRNAs in  Pancreatic Cancer: Therapeutic Potential, Delivery Challenges and Strategies. (Advanced Drug Deliv. Rev., 2015, 81, 34-52).
  43. Deepak Chitkara, Anupama Mittal, Ram I. Mahato, Neeraj Kumar. Core-shell Nanoparticulate Formulation of Gemcitabine: Lyophilization, Stability studies and In Vivo Evaluation. (Drug Deliv. Transl. Res. 2014, 439-51).
  44. Anupama Mittal, Ravinder Kumar, Devinder Prasad and Neeraj Kumar, Cytomodulin functionalized porous PLGA particulate scaffolds respond better to cell migration, actin production and wound healing in rodent model. (J. Tissue Eng. Regen. Med., 2014, 8, 351-63).
  45. Deepak Chitkara, Anupama Mittal, Stephan Behrman, Neeraj Kumar and Ram I. Mahato, Self-assembling, amphiphilic polymer-gemcitabine conjugate shows enhanced antitumor efficacy against human pancreatic adenocarcinoma. (Bioconjugate Chemistry, 2013, 24, 1161-73). 
  46. Anupama Mittal and Neeraj Kumar, Drug loaded polymeric composite skin graft for infection-free wound healing: fabrication, characterization, cell proliferation, migration and antimicrobial activity (Pharm. Res., 2012, 11, 3110-21).
  47. Anupama Mittal, Phaneedra Kurapati, Deepak Chitkara and Neeraj Kumar, In vitro release behavior of paclitaxel and carboplatin from poly (L-lactide) microspheres dispersed in thermosensitive biodegradable gel for combination therapy. (Int. J. Drug Deliv., 2011, 3, 245-259).
  48. Kalpna Garkhal, Anupama Mittal, Shalini Verma and Neeraj Kumar, P-15 functionalized porous microspheres as biomimetic habitats for musculoskeletal tissue engineering. (Polym. Adv. Tech., 2011, 22, 190-198). 
  49. Deepak Chitkara, Sanjay Nikalaje, Anupama Mittal and Neeraj Kumar, Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model. (Drug Deliv. Trans. Res., 2010, 2, 112-123).
  50. Anupama Mittal, Poonam Negi, Kalpna Garkhal, Shalini Verma and Neeraj Kumar, Integration of porosity and bio-functionalization to form 3D scaffold: Cell culture studies and in vitro degradation. (Biomed. Mater., 2010, 5, 045001).
  51. Anupama Mittal, Deepak Chitkara and Neeraj Kumar, HPLC method for the determination of carboplatin and paclitaxel with cremophor EL in an amphiphilic polymer matrix. (J.  Chromatograph. B, 2007, 85, 211-217).
  52. Shalini Verma, Kalpna Garkhal, Anupama Mittal and Neeraj Kumar, Biodegradable polymers for emerging clinical use in tissue engineering, in “Biodegradable polymers in clinical use and clinical development”, 2011, (Eds. Abraham J. Domb, Neeraj Kumar, Aviva Ezra) John Wiley and Sons, Inc., ISBN No. 978-0-470-42475-9, 555-619.
  53. Anupama Mittal, Deepak Chitkara, Rajendra Pawar, Neeraj Kumar, Avi Domb and Ben Corn, Polymeric carriers for regional drug therapy, in “Smart Polymers: Production, study and application in biotechnology and biomedicine”, 2008 (Eds. Igor Galaev and Bo Mattiasson) CRC Publications, ISBN No. 978-0-8493-9161-3, 359-400. 

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