BITS Pilani

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Publications

Translational Nanomedicine Lab
 
 
 
 
Publications
 
Theme Issues
1. Drug and Nucleic Acid Delivery and Targeting to the Brain, Journal of Controlled release, Editors: Ram I Mahato and Deepak Chitkara
 
https://www.sciencedirect.com/journal/journal-of-controlled-release/special-issue/10B85SQBSPR 
 
2.  Nanotechnology-based Delivery Strategies for Protein and Peptide Therapeutics, Journal of Pharamcology and Experimental Therapeutics, Editors: Anupama Mittal and Deepak Chitkara
 
https://www.aspet.org/aspet/news/news/2022/10/12/call-for-papers-on-protein-and-peptide-therapeutics-for-the-journal-of-pharmacology-and-experimental-therapeutics 
 
Books Edited:

Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology. Edited by Deepak Chitkara, Anupama Mittal, and Ram I. Mahato (Editors), September 2018, CRC Press, Taylor Francis, Florida, USA

 
   Molecular Medicines for Cancer : Concepts and Applications of Nanotechnology book cover

 

 
S. No. Authors Title Publication Year Volume Pages
1 Lohia, Aayushi; Sahel, Deepak Kumar; Salman, Mohammad; Singh, Vivek; Mariappan, Indumathi; Mittal, Anupama; Chitkara, Deepak;  Delivery Strategies for CRISPR/Cas Genome editing tool for Retinal Dystrophies: challenges and opportunities Asian Journal of Pharmaceutical Sciences 2022    
2 Kandregula, Bhaskar; Narisepalli, Saibhargav; Chitkara, Deepak; Mittal, Anupama;  Exploration of Lipid-Based Nanocarriers as Drug Delivery Systems in Diabetic Foot Ulcer Molecular Pharmaceutics 2022    
3 Date, Tushar; Kuche, Kaushik; Chaudhari, Dasharath; Ghadi, Rohan; Sahel, Deepak Kumar; Chitkara, Deepak; Jain, Sanyog;  Hitting Multiple Cellular Targets in Triple-Negative Breast Cancer Using Dual-Action Cisplatin (IV) Prodrugs for Safer Synergistic Chemotherapy ACS Biomaterials Science & Engineering 2022    
4 Saini, Komal; Arora, Caamin; Saini, Megha; Sharma, Saurabh; Chitkara, Deepak; Kakkar, Vandita;  Preclinical safety of tetrahydrocurcumin loaded lipidic nanoparticles incorporated into tacrolimus ointment: In vitro and in vivo evaluation Food and Chemical Toxicology 2022 167 113260
5 Sahel, Deepak Kumar; Salman, Mohd; Azhar, Mohd; Goswami, Sangam Giri; Singh, Vivek; Dalela, Manu; Mohanty, Sujata; Mittal, Anupama; Ramalingam, Sivaprakash; Chitkara, Deepak;  Cationic lipopolymeric nanoplexes containing the CRISPR/Cas9 ribonucleoprotein for genome surgery Journal of Materials Chemistry B 2022    
6 Pukale, Sudeep Sudesh; Sahel, Deepak Kumar; Mittal, Anupama; Chitkara, Deepak;  Coenzyme Q10 loaded lipid-polymer hybrid nanoparticles in gel for the treatment of psoriasis like skin condition Journal of Drug Delivery Science and Technology 2022 76 103672
7 Alshahrani, Saad M; Thotakura, Nagarani; Sharma, Saurabh; Quadir, Sheikh Shahnawaz; Chaurawal, Nishtha; Sharma, Sumit; Chitkara, Deepak; Raza, Kaisar;  Influence of Nanocarrier Type on the Drug Delivery Aspects of Docetaxel: Empirical Evidences Journal of Pharmaceutical Innovation 2022   12-Jan
8 Chaurawal, Nishtha; Misra, Charu; Abul Barkat, Harshita; Jatyan, Reena; Chitkara, Deepak; Barkat, Md; Sharma, Teenu; Singh, Bhupinder; Raza, Kaisar;  Oral sorafenib-loaded microemulsion for breast cancer: evidences from the in-vitro evaluations and pharmacokinetic studies Scientific reports 2022 12 15-Jan
9 Jatyan, Reena; Singh, Prabhjeet; Sahel, Deepak Kumar; Karthik, YG; Mittal, Anupama; Chitkara, Deepak;  Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme Journal of Controlled Release 2022 350 494-513
10 Bajaj, Tania; Kaur, Vishav Prabhjot; Anwekar, Urvashi; Chitkara, Deepak; Singh, Charan;  Surface Modification of Micronized Drug Particles for Aerosolization Organ Specific Drug Delivery and Targeting to the Lungs 2022   347-370
11 KC, Sarathlal; Kakoty, Violina; Marathe, Sandhya; Chitkara, Deepak; Taliyan, Rajeev;  Exploring the neuroprotective potential of rosiglitazone embedded nanocarrier system on streptozotocin induced mice model of Alzheimer’s disease Neurotoxicity Research 2021 39 240-255
12 Bhat, Medha; Pukale, Sudeep; Singh, Saurabh; Mittal, Anupama; Chitkara, Deepak;  Nano-enabled topical delivery of anti-psoriatic small molecules Journal of Drug Delivery Science and Technology 2021   102328
13 Ansari, Imran; Chaturvedi, Animesh; Chitkara, Deepak; Singh, Saurabh;  CRISPR/Cas mediated epigenome editing for cancer therapy Seminars in Cancer Biology 2021    
14 Bhat, Medha; Jatyan, Reena; Mittal, Anupama; Mahato, Ram I; Chitkara, Deepak;  Opportunities and challenges of fatty acid conjugated therapeutics Chemistry and Physics of Lipids 2021 236 105053
15 Mazumdar, Samrat; Chitkara, Deepak; Mittal, Anupama;  Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers Acta Pharmaceutica Sinica B 2021 11 903-924
16 Italiya, Kishan S; Singh, Arihant K; Chitkara, Deepak; Mittal, Anupama;  Nanoparticulate tablet dosage form of lisofylline-linoleic acid conjugate for type 1 diabetes: in situ single-pass intestinal perfusion (SPIP) studies and pharmacokinetics in rat AAPS PharmSciTech 2021 22 12-Jan
17 Salunkhe, Shubham A; Chitkara, Deepak; Mahato, Ram I; Mittal, Anupama;  Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis Advanced Drug Delivery Reviews 2021 173 394-415
18 KC, Sarathlal; Kakoty, Violina; Krishna, Kowthavarapu Venkata; Dubey, Sunil Kumar; Chitkara, Deepak; Taliyan, Rajeev;  Neuroprotective efficacy of co-encapsulated rosiglitazone and vorinostat nanoparticle on streptozotocin induced mice model of Alzheimer disease ACS Chemical Neuroscience 2021 12 1528-1541
19 Singh, Aditi; Tijore, Ajay; Margadant, Felix; Simpson, Chloe; Chitkara, Deepak; Low, Boon Chuan; Sheetz, Michael;  Enhanced tumor cell killing by ultrasound after microtubule depolymerization Bioengineering & Translational Medicine 2021   e10233
20 Ansari, Imran; Singh, Prabhjeet; Mittal, Anupama; Mahato, Ram I; Chitkara, Deepak;  2, 2-Bis (hydroxymethyl) propionic acid based cyclic carbonate monomers and their (co) polymers as advanced materials for biomedical applications Biomaterials 2021 275 120953
21 Sharma, Saurabh; Pukale, Sudeep; Sahel, Deepak Kumar; Singh, Prabhjeet; Mittal, Anupama; Chitkara, Deepak;  Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment Materials Science and Engineering: C 2021 128 112305
22 Agarwal, Devesh S; Mazumdar, Samrat; Italiya, Kishan S; Chitkara, Deepak; Sakhuja, Rajeev;  Bile-Acid-Appended Triazolyl Aryl Ketones: Design, Synthesis, In Vitro Anticancer Activity and Pharmacokinetics in Rats Molecules 2021 26 5741
23 Pukale, Sudeep Sudesh; Mittal, Anupama; Chitkara, Deepak;  Topical Application of Vitamin D3-Loaded Hybrid Nanosystem to Offset Imiquimod-Induced Psoriasis AAPS PharmSciTech 2021 22 17-Jan
24 Singh, Arihant Kumar; Italiya, Kishan S; Narisepalli, Saibhargav; Chitkara, Deepak; Mittal, Anupama;  Role of Chain Length and Degree of Unsaturation of Fatty Acids in the Physicochemical and Pharmacological Behavior of Drug–Fatty Acid Conjugates in Diabetes Journal of Medicinal Chemistry 2021 64 14217-14229
25 Sarathlal, KC; Kakoty, Violina; Krishna, Kowthavarapu Venkata; Dubey, Sunil Kumar; Chitkara, Deepak; Taliyan, Rajeev;  Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer Disease ACS chemical neuroscience 2021 12 1528-1541
26 Salunkhe, Shubham; Basak, Moumita; Chitkara, Deepak; Mittal, Anupama;  Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance Journal of Controlled Release 2020 326 599-614
27 Pukale, Sudeep Sudesh; Sharma, Saurabh; Dalela, Manu; kumar Singh, Arihant; Mohanty, Sujata; Mittal, Anupama; Chitkara, Deepak;  Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice Acta Biomaterialia 2020 115 393-409
28 Sharma, Saurabh; Pukale, Sudeep Sudesh; Mittal, Anupama; Chitkara, Deepak;  Docetaxel and its nanoformulations: how delivery strategies could impact the therapeutic outcome? Therapeutic Delivery 2020 11 755-759
29 Singh, Prabhjeet; Singh, Aditi; Shah, Shruti; Vataliya, Jalpa; Mittal, Anupama; Chitkara, Deepak;  RNA interference nanotherapeutics for treatment of glioblastoma multiforme Molecular Pharmaceutics 2020 17 4040-4066
30 Nandi, Tania; Pradyuth, Sai; Singh, Arihant Kumar; Chitkara, Deepak; Mittal, Anupama;  Therapeutic agents for targeting desmoplasia: current status and emerging trends Drug Discovery Today 2020 25 2046-2055
31 Sharma, Saurabh; Pukale, Sudeep Sudesh; Sahel, Deepak K; Agarwal, Devesh S; Dalela, Manu; Mohanty, Sujata; Sakhuja, Rajeev; Mittal, Anupama; Chitkara, Deepak;  Folate-targeted cholesterol-grafted lipo-polymeric nanoparticles for chemotherapeutic agent delivery AAPS PharmSciTech 2020 21 21-Jan
32 Italiya, Kishan S; Mazumdar, Samrat; Sharma, Saurabh; Chitkara, Deepak; Mahato, Ram I; Mittal, Anupama;  Self-assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus Nanomedicine: Nanotechnology, Biology and Medicine 2019 15 175-187
33 Thotakura, Nagarani; Sharma, Saurabh; Khurana, Rajneet Kaur; Babu, Penke Vijaya; Chitkara, Deepak; Kumar, Vipin; Singh, Bhupinder; Raza, Kaisar;  Aspartic acid tagged carbon nanotubols as a tool to deliver docetaxel to breast cancer cells: Reduced hemotoxicity with improved cytotoxicity Toxicology in Vitro 2019 59 126-134
34 Kothari, Ishit R; Mazumdar, Samrat; Sharma, Saurabh; Italiya, Kishan; Mittal, Anupama; Chitkara, Deepak;  Docetaxel and alpha-lipoic acid co-loaded nanoparticles for cancer therapy Therapeutic Delivery 2019 10 227-240
35 Sahel, Deepak Kumar; Mittal, Anupama; Chitkara, Deepak;  CRISPR/Cas system for genome editing: progress and prospects as a therapeutic tool Journal of Pharmacology and Experimental Therapeutics 2019 370 725-735
36 Singh, Anupama; Thotakura, Nagarani; Singh, Bhupinder; Lohan, Shikha; Negi, Poonam; Chitkara, Deepak; Raza, Kaisar;  Delivery of docetaxel to brain employing piperine-tagged PLGA-aspartic acid polymeric micelles: improved cytotoxic and pharmacokinetic profiles AAPS PharmSciTech 2019 20 9-Jan
37 Italiya, Kishan S; Basak, Moumita; Mazumdar, Samrat; Sahel, Deepak K; Shrivastava, Richa; Chitkara, Deepak; Mittal, Anupama;  Scalable self-assembling micellar system for enhanced oral bioavailability and efficacy of lisofylline for treatment of type-I diabetes Molecular Pharmaceutics 2019 16 4954-4967
38 Date, Tushar; Nimbalkar, Vaishnavi; Kamat, Jyostna; Mittal, Anupama; Mahato, Ram I; Chitkara, Deepak;  Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics Journal of controlled release 2018 271 60-73
39 Mazumdar, Samrat; Italiya, Kishan S; Sharma, Saurabh; Chitkara, Deepak; Mittal, Anupama;  Effective cellular internalization, cell cycle arrest and improved pharmacokinetics of Tamoxifen by cholesterol based lipopolymeric nanoparticles International Journal of Pharmaceutics 2018 543 96-106
40 Sharma, Saurabh; Mazumdar, Samrat; Italiya, Kishan S; Date, Tushar; Mahato, Ram I; Mittal, Anupama; Chitkara, Deepak;  Cholesterol and Morpholine grafted cationic Amphiphilic copolymers for miRNA-34a delivery Molecular Pharmaceutics 2018 15 2391-2402
41 Kothari, Ishit R; Italiya, Kishan S; Sharma, Saurabh; Mittal, Anupama; Chitkara, Deepak;  A rapid and precise liquid chromatographic method for simultaneous determination of alpha lipoic acid and docetaxel in lipid-based Nanoformulations Journal of chromatographic science 2018 56 888-894
42 Uppal, Siddharth; Italiya, Kishan S; Chitkara, Deepak; Mittal, Anupama;  Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: An emerging paradigm for effective therapy Acta Biomaterialia 2018 81 20-42
43 Mharugde, Vinayak Sadashiv; Pukale, Sudeep; Sharma, Saurabh; Mittal, Anupama; Chitkara, Deepak;  Advancements in Polymeric Systems for Nucleic Acid Delivery   2018    
44 Kumar, Pramod; Kumar, Rajendra; Singh, Bhupinder; Malik, Ruchi; Sharma, Gajanand; Chitkara, Deepak; Katare, OP; Raza, Kaisar;  Biocompatible phospholipid-based mixed micelles for tamoxifen delivery: promising evidences from in-vitro anticancer activity and dermatokinetic studies Aaps pharmscitech 2017 18 2037-2044
45 Sharma, Saurabh; Italiya, Kishan; Mittal, Anupama; Chitkara, Deepak;  New strategies for cancer management: how can temozolomide carrier modifications improve its delivery? Therapeutic Delivery 2017 8 475-477
46 Italiya, Kishan S; Sharma, Saurabh; Kothari, Ishit; Chitkara, Deepak; Mittal, Anupama;  Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rat Journal of Chromatography B 2017 1061 49-56
47 Mittal, Anupama; Chitkara, Deepak;  Structural modifications in polymeric micelles to impart multifunctionality for improved drug delivery Therapeutic delivery 2016 7 73-87
48 Chitkara, Deepak; Singh, Saurabh; Mittal, Anupama;  Nanocarrier-based co-delivery of small molecules and siRNA/miRNA for treatment of cancer Therapeutic Delivery 2016 7 245-255
49 Thakur, Chanchal Kiran; Thotakura, Nagarani; Kumar, Rajendra; Kumar, Pramod; Singh, Bhupinder; Chitkara, Deepak; Raza, Kaisar;  Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen International journal of biological macromolecules 2016 93 381-389
50 Chitkara, Deepak; Mittal, Anupama; Mahato, Ram I;  miRNAs in pancreatic cancer: therapeutic potential, delivery challenges and strategies Advanced drug delivery reviews 2015 81 34-52
51 Mittal, Anupama; Chitkara, Deepak; Kumar, Neeraj; Pawar, Rajendra; Domb, Avi; Corn, Ben;  Regional Drug Therapy: Polymeric Carriers for Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 11 Volume Set 2015   6951-6972
52 Mittal, Anupama; Chitkara, Deepak; Behrman, Stephan W; Mahato, Ram I;  Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer Biomaterials 2014 35 7077-7087
53 Wen, Di; Chitkara, Deepak; Wu, Hao; Danquah, Michael; Patil, Renukadevi; Miller, Duane D; Mahato, Ram I;  LHRH-conjugated micelles for targeted delivery of antiandrogen to treat advanced prostate cancer Pharmaceutical research 2014 31 2784-2795
54 Chitkara, Deepak; Mittal, Anupama; Mahato, Ram I; Kumar, Neeraj;  Core-shell nanoparticulate formulation of gemcitabine: lyophilization, stability studies, and in vivo evaluation Drug delivery and translational research 2014 4 439-451
55 Singh, Saurabh; Chitkara, Deepak; Kumar, Virender; Behrman, Stephen W; Mahato, Ram I;  miRNA profiling in pancreatic cancer and restoration of chemosensitivity Cancer letters 2013 334 211-220
56 Chitkara, Deepak; Kumar, Neeraj;  BSA-PLGA-based core-shell nanoparticles as carrier system for water-soluble drugs Pharmaceutical research 2013 30 2396-2409
57 Chitkara, Deepak; Mittal, Anupama; Behrman, Stephan W; Kumar, Neeraj; Mahato, Ram I;  Self-assembling, amphiphilic polymer–gemcitabine conjugate shows enhanced antitumor efficacy against human pancreatic adenocarcinoma Bioconjugate chemistry 2013 24 1161-1173
58 Singh, Saurabh; Chitkara, Deepak; Mehrazin, Reza; Behrman, Stephen W; Wake, Robert W; Mahato, Ram I;  Chemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathway PloS one 2012 7 e40021
59 Chitkara, Deepak; Singh, Saurabh; Kumar, Virender; Danquah, Michael; Behrman, Stephen W; Kumar, Neeraj; Mahato, Ram I;  Micellar delivery of cyclopamine and gefitinib for treating pancreatic cancer Molecular pharmaceutics 2012 9 2350-2357
60 Chitkara, Deepak; Nikalaje, Sanjay K; Mittal, Anupama; Chand, Mahesh; Kumar, Neeraj;  Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model Drug delivery and translational research 2012 2 112-123
61 Mittal, Anupama; Kurapati, Phaneendra; Chitkara, Deepak; Kumar, Neeraj;  In vitro release behavior of paclitaxel and carboplatin from poly (L-lactide) microspheres dispersed in thermosensitive biodegradable gel for combination therapy International Journal of Drug Delivery 2011 3 245
62 Jain, Jay Prakash; Chitkara, Deepak; Kumar, Neeraj;  Polyanhydrides as localized drug delivery carrier: an update Expert opinion on drug delivery 2008 5 889-907
63 Mittal, Anupama; Chitkara, Deepak; Kumar, Neeraj;  HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix Journal of chromatography B 2007 855 211-219
64 Mittal, Anupama; Chitkara, Deepak; Kumar, Neeraj; Pawar, Rajendra; Domb, Avi; Corn, Ben;  Polymeric Carriers for Regional Drug Therapy Smart Polymers: Applications in Biotechnology and Biomedicine 2007 2 359
65 Chitkara, Deepak; Shikanov, Ariella; Kumar, Neeraj; Domb, Abraham J;  Biodegradable injectable in situ depot‐forming drug delivery systems Macromolecular bioscience 2006 6 977-990
 
 
Patent Details:
  1. Deepak Chitkara, Deepak K. Sahel, Kishan S. Italiya, Saurabh Sharma, Shruti Shah, Anupama Mittal, Reena Jatyan, Title: A Self- Assembling Drug Conjugate and method of preparation thereof. Indian Patent Application no. 201911018304, Filed on May 06, 2020, Applicant: Birla Institute of Technology and Science (BITS), Pilani (Complete Specification).
  2. Deepak Chitkara, Sudeep S. Pukale, Arihant K Singh, Anupama Mittal,  Saurabh Sharma, Title: A lipid-polymer hybrid nanoparticle,  Application no. 201921004214, Indian Patent Application filed on 02 Feb 2020; Published on 07 August 2020,  Applicant- Incisive Element LLC., USA
  3. Deepak Chitkara, Sudeep S. Pukale, Arihant K Singh, Anupama Mittal, Saurabh Sharma,  Title: A lipid-polymer hybrid nanoparticle,  Application no. PCT/IB2020/050819, International Bureau of the World Intellectual Property Organization (WIPO-PCT), filed on 02 Feb 2020; Published on 07 August 2020,  Applicant- Incisive Element LLC., USA 
  4. Anupama Mittal, Kishan S. Italiya, Samrat Mazumdar, Deepak Chitkara, Title: Orally active nanoformulation of lysofylline and composition thereof. Indian Patent Application no. 201911004346. Filed on  Feb 05, 2019. Published on 04th February 2019, Applicant: Birla Institute of Technology and Science (BITS), Pilani
  5. Rajeev Sakhuja, Devesh S Agarwal, Deepak Chitkara, Samrat Mazumdar, Title: Synthesis of new triazolyl linked bile acid ketones, Indian Patent Application no. 201911006301 filed on 18 Feb 2019, Applicant: Birla Institute of Technology and Science (BITS), Pilani 
  6. Anupama Mittal,  Kishan S. Italiya, Samrat Mazumdar, Deepak Chitkara. Title: Surfactant-free, self-assembling micelles of fatty acid conjugated to hydrophilic drug and method for preparing the same. Indian Patent Application No. 201711044842 Filed on 13 Dec 2017, First examination report filed on 17th July 2020. Applicant: Birla Institute of Technology and Science (BITS), Pilani

Book Chapters:

  1. Vinayak Sadashiv Mharugde,  Sudeep Pukale,  Saurabh Sharma,  Anupama Mittal,  Deepak Chitkara, Chapter 16: Advancement in Polymeric System for Nucleic Acid Delivery. In  Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology, In Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology, Eds. Deepak Chitkara, Anupama Mittal, and Ram I. Mahato, September 2018, CRC Press, Taylor Francis, Florida, USA
  2. Mittal, Anupama; Chitkara, Deepak; Kumar, Neeraj; Pawar, Rajendra; Domb, Avi; Corn, Ben. Polymeric Carriers for Regional Drug Therapy. 2007. Smart Polymers: Applications in Biotechnology and Biomedicine. 359.

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