| Project ID |
BITS-SRIP/D9F821/2026 |
| Project Title |
Herbal based formulation development (Nanogel) and its evaluation using In Vitro and In Viva assay for Psorasis and vitiligo management |
| Project Description |
Psoriasis is a chronic, multifactorial inflammatory skin disease characterized by proliferation of keratinocytes in the epidermis, thick, scaly, with erythematous plaques. Similarly, the vitiligo is also a common, disfiguring autoimmune disease characterized by destruction of functional melanocytes, resulting in depigmented macules and patches on the skin. The pathogenesis of both skin problems involves intricate relationships between genetic predisposition, autoimmune reactions, oxidative stress, and pro-inflammatory cytokines. Both the skin disorders/disease, not effectively managed. Also , we will design, characterize, and evaluate a novel, nano-engineered, thermoresponsive topical gel for the effective and localized treatment of psoriasis and Vitiligo. The formulation will integrates drug-loaded Soluplus–Chitosan polymeric nanoparticles, surface-functionalized with hyaluronic acid (HA) for enhanced skin targeting, and embedded within a 20% Pluronic-based thermosensitive gel.
The system is expected to be remains liquid at room temperature and undergoes in situ gelation at skin temperature, ensuring prolonged skin residence, sustained drug release, and improved lesion-specific delivery. This approach will overcomes significant limitations of conventional topical therapies, including poor penetration, frequent dosing, low retention, and systemic side effects.
The formulation will be extensively characterized and biologically validated using comprehensive physicochemical analyses (particle size, zeta potential, FT-IR, XRD, DSC, TGA, SEM, HPLC, and in vitro release) that will confirm -formulation stability, compatibility, and controlled drug delivery. |
| Project Discipline |
B. Pharm, M Pharm, MSc. Biotechnology . Pharm Biotech |
| Faculty Name |
Rajeev Taliyan |
| Department |
Department of Pharmacy |
