| Project ID |
BITS-SRIP/01AB0F/2026 |
| Project Title |
Development of Mechanochemical-Enabled Protocols for C–H Bond Functionalization Reactions |
| Project Description |
Mechanochemistry has emerged as an efficient and sustainable approach in organic synthesis, enabling chemical transformations through the direct application of mechanical force, most commonly via ball-milling techniques. In recent years, mechanochemical enabled reactions have attracted considerable attention due to their significant advantages over traditional thermally driven reactions, such as solvent-free or solvent-minimized conditions, reduced reaction times, lower energy consumption, and improved alignment with the principles of green chemistry.
Concurrently, C–H bond functionalization is a powerful strategy in modern organic synthesis, as it allows the direct transformation of inert C–H bonds into functional groups without the need for prefunctionalized substrates. This step-economical approach reduces waste generation, improves atom economy, and enhances overall synthetic efficiency. The combination of mechanochemical methods with C–H bond activation therefore represents a promising and environmentally benign strategy for the synthesis of complex and functional molecules.
The present project focuses on the development of mechanochemical protocols for C–H bond functionalization reactions, with particular emphasis on the synthesis of functionalized heterocyclic compounds. Ball-milling techniques will be employed to carry out these transformations under solvent-free or minimally assisted conditions. Key reaction parameters such as milling time, frequency, and catalyst loading will be optimized to achieve efficient and selective functionalization. Comparisons with conventional thermal methods will be made to highlight the benefits and challenges associated with mechanochemical C–H activation.
As part of this work, the candidate will gain hands-on experience in modern organic synthesis techniques, including the execution of mechanochemical reactions, product isolation, and purification and characterization of organic compounds using spectroscopic and analytical methods such as IR spectroscopy, NMR spectroscopy, and high-resolution mass spectrometry (HRMS). |
| Project Discipline |
Chemistry |
| Faculty Name |
Anil Kumar |
| Department |
Department of Chemistry |
